Absolutely. But not everything.
I would shy away from recommending you do truss rod adjustments. I am not a big fan of putting all that pressure on a bit of steel rod. If I tighten a truss rod I always clamp the neck to assist the truss rod do its job. Similarly, forget about wiring mods unless you have a good soldering iron and know how to use it.
Intonation is really only accurately done with a strobe tuner. A normal tuner won’t cut it. Also I do more than the 12 fret harmonic intonation you’ve heard about. Most people get the profile of the bridge saddles wrong (unless it’s a set profile like a Gibson bridge).
So what can you do yourself? Heaps.
Chris’ Guitar Tips
- If you had the guitar correctly set up then I strongly recommend that you stay with the same brand and gauge of string. The intonation should be OK.
- Clean the socket carefully with an ear bud occasionally, and clean the ends of your guitar leads. Metho will do.
- Keep your fretboard clean. Use a credit card and cloth to clean up against your frets. Then oil your rosewood board with lemon oil or a proprietary finger board oil.
- Keep the screws and nuts comfortably tight.
- Don’t be tempted to oil your tuning keys. The oil will soak into the wood.
- If your pots get scratchy you can spray it with a cleaner/lubricant. Never put WD40 near a guitar. Not even in the same room!
- Adjusting the action on the common Gibson bridge is easy. It’s more complicated on a Fender with individual saddle heights. The radius of the saddles have to match your neck or it will not play well.
- Adjust the balance between your pickups by adjusting the height of the pickup as a whole. It is safer not to adjust the individual pole pieces unless you are confident there is a good thread (you can’t do this on a Strat or Tele of course).
- Give you’re guitar body and neck a wipe after use, including your strings. I am a coated string convert.
- Leave your guitar to acclimatise in its case if it goes through large temperature changes. Do I need to say never leave your guitar in a freezing cold or boiling hot car?
If you do no more than those 10 things, you will have a guitar which you will enjoy playing for many years.